2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry

 St. Anton, Austria    January 19-23, 2020

Programme


17:00

Opening Remarks

17:30

Necessity is the Mother of Invention: Natural Products and the Chemistry They Inspire (KL01)

Prof. Sarah E. REISMAN
CALIFORNIA INSTITUTE OF TECHNOLOGY, Pasadena, United States

18:30

Poster Session & Welcome Reception

20:30

End of Day 1

Session 1: Predictive ADME Sciences: Striking a Balance Between In Silico and Experimental Work?

Session Chair

Dr Amit KALGUTKAR
PFIZER, Groton, United States

08:30

Structural Attributes Influencing Unbound Tissue Distribution (PL01)

Dr Li DI
PFIZER, Groton, United States

09:00

Metabolism of Strained Rings: Tales of the Unexpected (PL02)

Dr Martin HAYES
ASTRAZENECA, Gothenburg, Sweden

09:30

Coffee Break

10:00

Leveraging In Silico ADMET and Ancillary Pharmacology to Influence Selection of Chemical Series with Increase Probability of Success (PL03)

Dr Falgun SHAH
MERCK, West Point, United States

10:30

Title to be confirmed (PL04)

Dr Simone SCHADT
F. HOFFMANN-LA ROCHE, Basel, Switzerland

Dr Kenichi UMEHARA
ROCHE PHARMACEUTICAL RESEARCH AND EARLY DEVELOPMENT, Basel, Switzerland

11:00

Outdoor Networking Activities

15:45

Networking Break

16:00

NovAliX Workshop: DNA-Encoded Libraries, an Integrated Platform for Hit Finding and Beyond

Dr Julien MARIN
NOVALIX, Illkirch, France

Session 2: Frontiers of Synthetic Chemistry

Session Chair

Prof. Erick M. CARREIRA
ETH ZÜRICH, Zürich, Switzerland

17:00

Break-it-to-Make-it Strategies for Complex Molecule Synthesis (PL05)

Prof. Richmond SARPONG
UNIVERSITY OF CALIFORNIA, BERKELEY, Berkeley, United States

17:30

New Avenues in Synthesis Enabled by Organic Photoredox Catalysis (PL06)

Prof. David NICEWICZ
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, Chapel Hill, United States

18:00

Coffee Break

18:30

Late-Stage Functionalizations (PL07)

Prof. Tobias RITTER
MAX-PLANCK-INSTITUT FÜR KOHLENFORSCHUNG, Mulheim, Germany

19:00

A Radical Way to Abeo-Steroids (PL08)

Prof. Philipp HERETSCH
FREE UNIVERSITY OF BERLIN, Berlin, Germany

19:30

Poster Session

20:30

End of Poster Session

21:00

Conference Dinner

23:00

End of Day 2

Session 3: Structure and Biophysics - Companions for Medicinal Chemistry

Session Chair

Dr Wolfgang JAHNKE
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland

08:30

Membrane Proteins at the SGC – Challenges and Success Stories (PL09)

Dr Katharina DUERR
UNIVERSITY OF OXFORD, Oxford, United Kingdom

09:00

Title to be confirmed (PL10)

Dr Matthias FRECH
MERCK, Darmstadt, Germany

09:30

Coffee Break

10:00

Title to be confirmed (PL11)

Dr Xavier DARZACQ
UNIVERSITY OF CALIFORNIA, BERKELEY, Berkeley, United States

10:30

Discovery of Small Molecule Fascin 1 Inhibitors Using Fragment-Based Drug Discovery (OC02)

Dr Stuart FRANCIS
THE BEATSON INSTITUTE FOR CANCER RESEARCH, Glasgow, United Kingdom

11:00

Outdoor Networking Activities

15:00

Networking Break & "Beyond-the-Science Leadership Development" Workshop

Beyond-the-Science Leadership Development

Session Chair

Dr Michelle CLAFFEY
CLAFFEY LEADERSHIP, Norwich, United States

Session 4: Protein Degradation: New Rules for Drug Discovery

Session Chair

Prof. Alessio CIULLI
UNIVERSITY OF DUNDEE, Dundee, United Kingdom

17:00

Targeted Protein Degradation (PL12)

Prof. Andy PHILLIPS
C4 THERAPEUTICS, Watertown, United States

17:30

PL13 - Speaker to be confirmed

18:00

Four E3 Ligases, One Target: Towards Novel CDK6 Protacs (OC03)

Mr Christian STEINEBACH
UNIVERSITY OF BONN, Bonn, Germany

18:30

Coffee Break

19:00

Expanding the Druggable Genome through Cereblon-Mediated Protein Degradation (KL02)

Dr Lawrence G. HAMANN
CELGENE, Cambridge, United States

20:00

End of Day 3

Session 5: Innovation and Inspiration from Natural Products

Session Chair

Prof. Thomas MAGAUER
UNIVERSITY OF INNSBRUCK, Innsbruck, Austria

08:30

Discoveries and Surprises with Natural Products (PL14)

Prof. Karl GADEMANN
UNIVERSITY OF ZÜRICH, Zürich, Switzerland

09:00

Concise Synthesis of Complex Taxane Diterpene Canataxpropellane by Photochemical Dearomatization (PL15)

Prof. Tanja GAICH
UNIVERSITY OF KONSTANZ, Konstanz, Germany

09:30

Coffee Break

10:00

Strategies for the Synthesis of Bioactive Diterpenoids (PL16)

Prof. Christopher VANDERWAL
UNIVERSITY OF CALIFORNIA, IRVINE, Irvine, United States

10:30

Total Synthesis of Chivosazole F (OC04)

Dr Simon WILLIAMS
SYNGENTA, Stein AG, Switzerland

11:00

Outdoor Networking Activities

15:45

Networking Break & "Panel Discussion on Protein Degradation"

Session 6: Accelerating Drug Discovery by Intelligence Augmentation

Session Chair

Dr Thomas TRIESELMANN
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG, Biberach an der Riss, Germany

17:00

Organic Synthesis on a Computer: Should Medicinal Chemists Care? (PL17)

Prof. Bartosz A. GRZYBOWSKI
ULSAN NATIONAL INSTITUTE OF SCIENCE & TECHNOLOGY, Ulsan, Korea, South

17:30

Synthesis in the Chemical Space Age (PL18)

Prof. Timothy CERNAK
UNIVERSITY OF MICHIGAN, Ann Arbor, United States

18:00

Accelerating R&D with Augmented Intelligence (PL19)

Dr Matthias ZENTGRAF
BOEHRINGER INGELHEIM, Biberach an der Riss, Germany

18:30

Coffee Break

19:00

Oral Communication 05

19:30

Poster Session

20:30

End of Day 4

Session 7: Targeted Delivery - Strategies to Help your Drug Substances get to the Right Place

Session Chair

Dr Philippe NANTERMET
MERCK & CO. INC (MSD), West Point, United States

08:30

Discovery of Tumor Targeted TLR7/8 Immune-Stimulating Antibody Conjugates (ISAC) (PL20)

Dr Brian SAFINA
BOLT BIOTHERAPEUTICS, Redwood City, United States

09:00

Intracellular and Tissue Specific Targeting of Therapeutic Modalities (PL21)

Dr Vadim DUDKIN
JANSSEN DISCOVERY SCIENCES, Lansdale, United States

09:30

Coffee Break

10:00

Using Small Molecules to Engineer and Explore Human Immunity (PL22)


Prof. David SPIEGEL
YALE UNIVERSITY, New Haven, United States

10:30

Title to be confirmed (PL23)

Dr Valerie ODEGARD
SILVERBACK THERAPEUTICS, Seattle, United States

11:00

Outdoor Networking Activities

15:45

Networking Break

Session 8: Drug Discovery Tales

Session Chair

Dr Lena RIPA
ASTRAZENECA, Sweden

16:30

Discovery of GDC-0334: a potent and orally bioavailable clinical candidate for the inhibition of TRPA1 (OC07)

Dr Vishal VERMA
GENENTECH, South San Francisco, United States

17:00

Investigating the Chameleonic Properties of RGD Integrin Antagonists for the Treatment of IPF (OC08)

Mr James THOMPSON
GLAXOSMITHKLINE/UNIVERSITY OF STRATHCLYDE, Stevenage, United Kingdom

17:30

Discovery of AZD3458 a Highly Selective PI3Ky Inhibitor: Combining Structure, HDX-MS and Binding Kinetics to Understand the Mode of Action (OC09)

Dr Nils PEMBERTON
ASTRAZENECA, Mölndal, Sweden

18:00

The Discovery of a Potent and Orally Bioavailable Macrocyclic Cyclophilin Inhibitor Based on The Structural Simplification of Sanglifehrin A (OC 10)

Dr Vicky STEADMAN
EUROFINS DISCOVERY, Essex, United Kingdom

18:30

Coffee Break

18:30

The Big Impact of Small Changes : Towards Best-in-Class EZH2 and LSD1 Inhibitors (OC11)

Dr Julian LEVELL
CONSTELLATION PHARMACEUTICALS, Cambridge, United States

19:00

Controlling the Fate and Function of Proteins with Photopharmacology (KL03)

Prof. Dirk TRAUNER
NEW YORK UNIVERSITY, New York, United States

20:00

Closing Remarks

20:30

End of Symposium