3rd Alpine Winter Conference on Medicinal and Synthetic Chemistry

 Virtual Event    January 24-28, 2022

Programme



Methodologies to Understand Cellular Target Interaction

Session Chair

Prof. Per ARTURSSON
UPPSALA UNIVERSITY, Uppsala, Sweden
13:15

Opening

13:30

Intracellular Oligonucleotide Distribution and Protein Binding

Dr Alice GHIDINI
ASTRAZENECA, Gothenburg, Sweden
13:50

Exhibitor Presentation

13:55

Monitoring Drug Selectivity and Target Engagement Across Systems – Thermal Shift Assay in Drug Discovery

Dr Anna RUTKOWSKA-KLUTE
GSK, Heidelberg, Germany
14:15

Break

14:25

Molecular Chameleonicity and Cell Permeability of Drugs and PROTACs in the bRo5 Space

Prof. Jan KIHLBERG
UPPSALA UNIVERSITY, Uppsala, Sweden
14:45

Lessons in Transcellular Membrane Permeability Re-Learned

Dr Mike HANN
GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom
15:05

Session Discussion

15:25

End of Session

Targeting Unstructured Proteins

Session Chair

Dr Hasane RATNI
F. HOFFMANN-LA ROCHE LTD, Basel, Switzerland
15:55

Introduction

16:00

Innovative Strategies to Target Non-Coding RNAs with Synthetic Ligands

Dr Maria DUCA
UNIVERSITY OF CÔTE D'AZUR, Nice, France
16:20

Exhibitor Presentation

16:25

Title to be announced

16:45

Break

16:55

Drugging RNA – A Structure-based Approach

Dr Jacques DUMAS
ARRAKIS THERAPEUTICS, Boston, United States
17:15

Design and Discovery of Clinical Candidate eFT226, a First-in-Class Inhibitor of the RNA Helicase eIF4A

Dr Christian NILEWSKI
GENENTECH, South San Francisco, United States
17:35

Title to be announced


Prof. Angela KOEHLER
MIT KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH, Cambridge, United States
18:15

Session Discussion

18:45

End of the Day

10:15

Company Workshop(s)

11:00

Poster Session I

Automation and Machine Learning Applications for Medicinal Chemistry

Session Chair

Dr Michael WLEKLINSKI
MERCK & CO., INC., Kenilworth, United States
13:15

Introduction

13:20

Enabling Fragment-based Drug Discovery (FBDD) with Automated Synthesis Technologies

Dr Rachel GRAINGER
ASTEX PHARMACEUTICALS, Cambridge, United Kingdom
13:40

Exhibitor Presentation

13:45

Rapid Development of Robust Reactions and Multi-Step Syntheses

Prof. Alexei LAPKIN
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom
14:05

Break

14:15

High-Throughput Experimentation Capabilities to Accelerate Discovery Chemistry

Dr Iulia STRAMBEANU
JOHNSON AND JOHNSON, King of Prussia, United States
14:35

Session discussion

14:55

End of Session

Increasing sp3 Fragment Options: Advances in the Synthesis of Small Ring Systems

Session Chair

Dr James MOUSSEAU
HALDA THERAPEUTICS, New Haven, United States
15:25

Introduction

15:30

Exploring and exploiting propellanes

Prof. Ed ANDERSON
UNIVERSITY OF OXFORD, Oxford, United Kingdom
15:50

Exhibitor Presentation

15:55

The Next Generation of BCPs: Exploring Substitutions on the Bridge

Dr Xiaoshen MA
MERCK & CO., INC, Boston, United States
16:15

Break

16:25

Synthesis and Functionalization of Cyclopropane Derivatives

Dr Sophie ROUSSEAUX
UNIVERSITY OF TORONTO, Toronto, Canada
16:45

No Strain, No Gain: Advances in the Synthesis and Design of New Classes of Building Blocks

Prof. Kevin BROWN
INDIANA UNIVERSITY, Bloomington, United States
17:05

Session Discussion

17:25

End of the Day

17:30

Partnering Event

10:30

Company Workshop(s)

Understanding PK and PK/PD relationships in drug discovery - Target Mediated Drug Disposition

Session Chair

Dr Stephanie HARLFINGER
ASTRAZENECA, Cambridge, United Kingdom
13:15

Introduction

13:20

Concept of Pharmacologic Target-Mediated Drug Disposition (TMDD) in Large-Molecule and Small-Molecule Compounds

Prof. Guohua AN
THE UNIVERSITY OF IOWA COLLEGE OF PHARMACY, Iowa City, United States
13:40

Exhibitor Presentation

13:45

Understanding the PKPD and ADME of PF-07059013: An Allosteric Modulator of a High Abundance Target

Dr Kevin BEAUMONT
ASTRAZENECA, Cambridge, United Kingdom
14:05

Break

14:15

Basic Concepts in TMDD

Dr David FAIRMAN
GSK, Cambridge, United Kingdom
14:35

Importance of Mechanistic Models in AHD Prediction

Dr Birgit SCHOEBERL
NOVARTIS INSTITUTE FOR BIOMEDICAL RESEARCH, Cambridge, MA, United States
14:55

Session Discussion

15:15

End of Session

Drug Discovery Tales (I)

Session Chair

Dr Nadia M. AHMAD
CHARLES RIVER LABORATORIES, Harlow, United Kingdom
15:45

Introduction

15:50

Title to be announced

16:10

Exhibitor Presentation

16:15

Title to be announced

16:35

Break

16:45

Title to be announced

Dr Wendy YOUNG
MPM CAPITAL POWERING BREAKTHROUGHS IN LIFE SCIENCES, Brisbane, United States
17:25

Session Discussion

17:45

End of the Day

10:15

Company Workshop(s)

11:00

Poster Session II

Drug Discovery Tales (II)

Session Chair

Dr Nadia M. AHMAD
CHARLES RIVER LABORATORIES, Harlow, United Kingdom
13:15

Introduction

13:20

Title to be announced

13:40

Exhibitor Presentation

13:45

Title to be announced

14:05

Break

14:15

Title to be announced

14:35

Title to be announced

14:55

Session Discussion

15:15

End of Session

Covalent Targeting: Innovating for the Future

Session Chair

Dr Vishal VERMA
GENENTECH, INC., South San Francisco, United States
15:45

Introduction

15:50

Title to be announced

Dr Matthew CHEESEMAN
THE INSTITUTE OF CANCER RESEARCH, Sutton, United Kingdom
16:10

Exhibitor Presentation

16:15

Reversible-covalent Inhibitors of the Kinase Activity of FGFR4

Dr Robin FAIRHURST
NOVARTIS, Basel, Switzerland
16:35

Break

16:45

Studies with Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors

Dr Agustin CASIMIRO-GARCIA
PFIZER, United States
17:05

Session Discussion

17:25

End of the Day

17:30

Partnering Event

The "Catalytic Cycle" of Complex Molecule Synthesis and Methodology Development

Session Chair

Prof. Tanja GAICH
UNIVERSITY OF KONSTANZ, Konstanz, Germany
13:00

Introduction

13:05

Title to be announced

13:25

Exhibitor Presentation

13:30

Title to be announced

Prof. Ang LI
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, Shanghai, China
13:50

Break

14:00

Title to be announced

Prof. Ruben MARTIN
INSTITUTE OF CHEMICAL RESEARCH OF CATALONIA, Tarragona, Spain
14:20

Computationally Augmented Total Synthesis

Dr Timothy NEWHOUSE
YALE UNIVERSITY, New Haven, United States
14:40

Functionalization of N-Heterocycles using Li, Mg, and Zn Organometallics

Prof. Paul KNOCHEL
LUDWIG MAXIMILIANS UNIVERSITY, Munich, Germany
15:20

Session Discussion

15:50

Closing Ceremony

16:00

End of Alpine Winter Conference 2022