St. Anton, Austria January 28-February 1, 2024
For each of the below topics, a slot in the programme will be available for an oral communication to be selected out of the submitted abstracts.
Extension of the medicinal chemistry toolbox is in the vital interest of drug designers who are confronted with the task of finding molecular solutions for an ever-increasing biological target space in a timely manner. However, in the daily routine, medicinal chemists often tend to stick to the functional groups and structural elements they know and love.
This session intends to provide inspiration for the utilization of non-mainstream moieties in drug discovery to overcome optimization hurdles.
Viral diseases have had a profound impact on human health. Since the beginning of the 21st century the World Health Organization has declared fourteen infectious disease related public health emergencies eight of which are viral in origin and include SARS, Influenza H1N1, Ebola, MERS, Zika, SARS-CoV-2 and Monkeypox. In addition, chronic viral diseases such as HIV, HCV, HBV, HSV and HPV continue to burden both the developed and underdeveloped regions of the world. To compound the situation, there is a growing concern around the emergence of resistant variants of known viral pathogens and the potential for the emergence of new viruses. These heightened concerns are fueled by an increase in population density and urbanization, increases in global travel and migration and the impact of climate change.To counter the continual threat of viral diseases, it is imperative that focus be maintained not only on the development of vaccines to control the emergence of viral diseases within a population but also on the development of novel antiviral drugs to combat these infections once they take hold within a population. The success of antiviral drugs in combating global public health challenges can be seen in the treatments developed to combat HIV infection and the cures developed for HCV. To achieve such success, required that all available tools in the drug discovery toolbox including genomics, structural biology, computational chemistry, high throughput screening and modern chemical synthetic methods be leveraged. This session on Antiviral Drug Discovery will highlight progress in the discovery of novel agents to treat viral infections, and the strategies and methods used to deliver these agents to the clinic.
Targeted therapies have expectation of broadened therapeutic window due to tumor-specific drug delivery. In the field of targetted therapies, the antibody drug conjugate (ADC) space is continuing to make major breakthroughs "from bench to clinic" and proving its potential as a safe, efficacious, and cost-effective treatment. Notable achievements in the field include ImmunoGen submitting a BLA for Mirvetuximab soravtansine, Enhertu showing efficacy in HER2-low breast cancer, and 16 new ADCs entering first in human studies. These recent successes are opening a new chapter in the story of antibody-drug conjugates, paving a well-defined pathway to change the future of oncology treatments. In this session we want to highlight recent developments in this field.
In recent years, cryo-electron microscopy (cryo-EM) has become a key technology for the structure-based design of drugs targeting disease-relevant macromolecules. This has been particularly transformative for drug targets which are not suitable for other structural methods (X-ray crystallography or NMR), such as integral membrane proteins. Advances in detector technology and image processing software have made this technique now broadly applicable for routine high-resolution structure determination of GPCR/G protein complexes, ion channels, solute carriers and other challenging targets.
In this session, speakers from academia and industry will present examples of how cryo-EM has contributed to small molecule design and how it can be even implemented for high-throughput approaches such as fragment-based screening pipelines.